Are your SharePoint error logs full of 6482?
Are your audiences failing to compile?
Did you try resetIIS and that only helped for a little bit, if at all?
Then you need Microsoft Hotfix 946517!!
Available now on web browsers worldwide!!
Thanks to this thread: http://social.technet.microsoft.com/Forums/en-US/sharepointadmin/thread/7aeab1ba-0b16-43ee-b0c0-aafcc90ae293